From 2021 to 2028, the global Gene Amplification Technologies Market is predicted to grow at a CAGR of 8.6%, from US$ 26,489 Million in 2020 to US$ 50,636 Million by 2028.

Gene amplification is a biological process in which copies of a gene or genes are produced to increase the phenotype that the gene confers on the cell. Gene amplification is a genetic aberration that occurs frequently in human cancer cells and involves many additional copies of a subchromosomal DNA region (amplicon). Extrachromosomal double-minute chromosomes (dmins) or chromosomally integrated homogeneously stained areas are cytogenetically indicative of amplification (HSRs). Mutations may be the cause of naturally occurring gene amplification. Mutations can occur as a result of errors in DNA replication and repair. A mutation is a change in a gene's or chromosome's nucleotide sequence. Uneven crossing-over between mismatched homologous chromosomes during meiosis, aneuploidy, polyploidy, retrotransposition, and replication slippage are all possible causes of gene amplification.

Market Dynamics

The increasing prevalence of cancer in the world is the primary factor boosting the gene amplification technologies market. Amplification of a gene occurs when the copy number of a certain section of a chromosomal arm increases. It's common in various cancers, and it's linked to overexpression of the amplified gene (s). Extrachromosomal elements, repeating units at a single locus, and dispersed amplified DNA can all be found in the genome. Amplification could be aided by chromosomal fragile spots, DNA replication abnormalities, or telomere malfunction. Although some amplification sites are complicated, aspects of the pattern are replicated in various tumor types. The relative frequency of amplification in specific tumor subtypes, as well as its prevalence in 'early' preneoplastic lesions, point to a genetic origin. Amplification serves as a predictive and diagnostic tool in the clinic, as well as a mechanism of acquired drug resistance.

Growing research & development in the molecular diagnostics field is another important aspect that propels the gene amplification technologies industry. Molecular diagnostic tools such as polymerase chain reaction (PCR), sequencing, hybridization, and microarray have aided clinicians by providing rapid and sensitive approaches for screening, detection, and monitoring of a wide range of genetic disorders, cancers, infectious diseases, and chronic diseases. Even the most industrialized countries' healthcare systems have been put to the test by the COVID-19 epidemic. A developing country such as India has been improving and expanding its testing approach in response to the changing paradigm, which is in line with the scope, necessity, and capacity to rapidly scale-up tests that must be undertaken. Until now, the government's 3Ts strategy of testing, monitoring, and tracing has played a key role in virus containment. However, the high cost of this technology is restricting the market from growing during the forecast period 2021 – 2028.

Market Insights

Product, sample type, technology, application, end-use, and regions are the segmentations of the global gene amplification technologies market. Among product types, the market categorizes them as instruments, kits & reagents, and services. Sample type segmentation includes single cells, FFPE, and others. Technologies are split into PCR-based amplification, nucleic acid sequence-based amplification, multiple displacement amplification, strand displacement amplification, loop-mediated isothermal amplification, ramification amplification, rolling circle amplification, and others. Exome sequencing, whole genome amplification, SNP genotyping arrays, hybridization, array CGH, and others are covered under the application segment. Furthermore, the end-use segment is categorized into academic & research institutes, pharmaceutical & biotechnology companies, and others.

Gene Amplification Technologies Market Regional Overview

North America, Asia-Pacific, Latin America, Europe, and the Middle East & Africa are the segmentation of the global gene amplification technologies industry. By regions, North America gathered a maximum amount of share in 2020 due to the existence of numerous healthcare facilities, growth in genetic testing, and increasing research programs in the region. Moreover, the rising government spending on medical research and its infrastructure is also supporting regional growth. However, the Asia-Pacific region is likely to exhibit the fastest growth rate due to the growing prevalence of numerous diseases, favorable government initiatives for genomic research, and an increasing number of healthcare and research facilities such as China and India.

Global Gene Amplification Technologies Segment Analysis

Market By Product

·         Instruments

·         Kits & Reagents

·         Services

Market By Sample Type

·         FFPE

·         Single Cell

·         Others

Market By Technology

·         PCR-Based Amplification

·         Multiple Displacement Amplification

·         Nucleic Acid Sequence-Based Amplification

·         Strand Displacement Amplification

·         Loop-Mediated Isothermal Amplification

·         Rolling Circle Amplification

·         Ramification Amplification

·         Others

Market By Application

·         Exome Sequencing

·         Whole Genome Amplification

·         SNP Genotyping Arrays

·         Array CGH

·         Hybridization

·         Others

Market By End-Use

·         Academic & Research Institutes

·         Pharmaceutical & Biotechnology Companies

·         Others

Gene Amplification Technologies Market Competitive Landscape

This section of the report identifies the market's major players. Abbott Laboratories, Ambion, Inc., Agilent Technologies, Inc., Bio-Rad Laboratories, Danaher Corporation, Illumina Inc., QIAGEN N.V., Merck KGaA, Promega Corporation, Silicon Biosystems, Vazyme Biotech Co. Ltd., and Takara Bio, Inc. are the key companies mentioned in the research.

Gene Amplification Technologies Market Regional Overview

North America

·         U.S.

·         Canada

Europe

·         U.K.

·         Germany

·         France

·         Spain

·         Rest of Europe

Latin America

·         Brazil

·         Mexico

·         Rest of Latin America

Asia-Pacific

·         China

·         Japan

·         India

·         Australia

·         South Korea

·         Rest of Asia-Pacific

Middle East & Africa

·         GCC

·         South Africa

·         Rest of Middle East & Africa