The Global Peptide Synthesis Market Size was valued at USD 572.4 Million in 2023 and is anticipated to reach USD 1,066.7 Million by 2032 with a CAGR of 7.3% from 2024 to 2032.

Peptide synthesis is the process of producing peptides, which are short chains of amino acids connected together by peptide bonds. This can be accomplished chemically using solid-phase peptide synthesis (SPPS) or biologically via recombinant DNA technology. Peptides are commonly employed in the pharmaceutical industry to produce medications to treat cancer, diabetes, and infectious disorders. They also have an important function in diagnostics, biomarker identification, and vaccine development. In addition, peptides are used in cosmetic formulations and as research tools to investigate protein activities and interactions.

According ACS Publications, in recent years, there has been an increasing interest in therapeutic peptides in the pharmaceutical sector, with over 50 peptide medications on the market, around 170 in clinical trials, and more than 200 in preclinical research.

Peptide Synthesis Market Dynamics

The rising frequency of chronic diseases such as cancer, diabetes, and autoimmune disorders has increased the demand for peptide-based therapies. According to the US Department of Health and Human Services, an estimated 129 million people in the United States suffer from at least one severe chronic condition (for example, heart disease, cancer, diabetes, obesity, or hypertension). Furthermore, peptides have great selectivity, less side effects, and tailored actions, making them ideal for therapeutic development.

Peptide synthesis processes have become more efficient, cost-effective, and scalable because to technological advances such as automated synthesizers and improved chemical reagents. For example, in January 2022, Novo Nordisk India, a renowned global healthcare business, launched oral semaglutide, a peptide in a pill used to control diabetes. GLP-1 receptor analogues (GLP-1 RAs), one of the medication groups used to treat diabetes, were previously only available as injections. Oral semaglutide is a co-formulation of GLP-1RA semaglutide and the absorption enhancer SNAC, which prevents semaglutide from degrading in the stomach like other peptides and increases its absorption. These advances have accelerated the development and commercialization of peptide-based medicines and therapies.

Despite technological advancements, peptide synthesis remains expensive due to the complexities of the manufacturing and purifying procedures. This may hinder the pricing and widespread adoption of peptide-based medications, particularly in emerging markets.

The emerging trend of individualized treatment opens up tremendous prospects for peptide synthesis. For example, as part of Illumina's oncology product range, Pillar Biosciences and Illumina signed a strategic alliance in July 2023 to commercialize Pillar's suite of oncology tests globally. Completing the arrangement will result in an unprecedented provision of new next-generation sequencing (NGS) solutions, increasing patient access to tailored cancer treatment options. This collaboration will propel the peptide synthesis industry forward by accelerating the discovery of peptide-based cancer treatments and diagnostics for tailored treatment, therefore increasing demand for specialized peptides in oncology. Tailored peptide-based medicines can be produced to meet individual genetic profiles, increasing therapeutic success and patient satisfaction.

Global Peptide Synthesis Market Segment Analysis

Peptide Synthesis Market By Product

·       Reagents & Consumables

o   Resins

o   Amino Acids

o   Coupling Reagents

o   Dyes & Fluroscent Labeling Reagents

o   Others

·       Equipment

o   Peptide Synthesizers

o   Lyophilizers

o   Chromatography Equipment

o   Others

·       Others

According to the peptide synthesis market, reagents and consumables are dominant due to their importance in the peptide synthesis process. These comprise amino acids, coupling agents, solvents, and resins, which are required for proper peptide chain building and purification. As the demand for high-quality peptides rises, so does the requirement for improved reagents and consumables, resulting in market dominance. Furthermore, improvement in reagent formulations and packaging leads to higher yields and lower costs, strengthening their importance in peptide synthesis.

Peptide Synthesis Market By Technology

·       Hybrid Technology

·       Solid Phase Peptide Synthesis (SPPS)

·       Liquid Phase Peptide Synthesis (LPPS)

As per the peptide synthesis industry analysis, liquid phase peptide synthesis (LPPS) dominates because of its versatility and capacity to synthesize longer, more pure peptide. LPPS provides greater control over the synthesis process, making it ideal for large-scale peptide manufacturing. It also makes it easier to synthesize complicated peptide sequences, which are important in therapeutic applications. While more labor-intensive than solid-phase procedures, LPPS remains necessary for certain peptide requirements, particularly in academic and research contexts.

Peptide Synthesis Market By Application

·       Therapeutics

o   Cancer

o   Metabolic

o   Cardiovascular Disorder

o   Respiratory

o   GIT (Gastrointestinal Disorders)

o   Infectious Diseases

o   Pain

o   Dermatology

o   CNS

o   Renal

o   Others

·       Diagnosis

·       Research

As per the peptide synthesis market forecast, therapeutics are gaining popularity as peptides are recognized for their potential to cure a variety of ailments such as cancer, diabetes, and neurological disorders. Peptide-based medications have several advantages, including high specificity, and fewer side effects. Pharmaceutical companies' expanding investment in peptide treatments drives innovation and increases demand for peptide synthesis. With breakthroughs in formulation and delivery technologies, peptide therapies are becoming a primary target for novel medication development.

Peptide Synthesis Market By End Use

·       Academic & Research Institutes

·       Pharmaceutical & Biotechnology Companies

·       Contract Development & Manufacturing Organization/Contract Research Organization

As per the peptide synthesis market forecast, pharmaceutical and biotechnology industries are quickly expanding due to their substantial research and development skills, which enable the manufacturing of innovative peptide-based therapies. These firms make significant investments in peptide drug research and development to meet unmet medical needs, such as targeted cancer medicines and metabolic disorders. Their modern facilities and peptide synthesis skills allow the creation of high-quality, bioactive peptides suitable for clinical trials and commercial applications. As a result, pharmaceutical and biotechnology companies continue to be significant drivers of market growth and innovation in the peptide synthesis business.

Peptide Synthesis Market Regional Analysis

North America dominates the peptide synthesis market due to its strong pharmaceutical and biotechnology industries, which include top firms and significant R&D investments. For example, in July 2024, CordenPharma announced plans to invest USD 980 million in expanding its existing peptide manufacturing facility in the United States and constructing a new production site in Europe. The region has excellent technological infrastructure, regulatory support, and a strong market for peptide-based therapies. Furthermore, North America's healthcare system and research institutions contribute significantly to market growth.

Asia-Pacific is quickly rising in the peptide synthesis market as a result of increased investments in biotechnology and pharmaceutical industries, particularly in China and India. For example, WuXi AppTec said in January 2024 that it would expand its peptide synthesis capacity by opening two additional facilities in China. The region benefits from expanding healthcare demand, the incidence of chronic diseases, and a shift toward biopharmaceuticals. Furthermore, cost-effective production and a huge skill pool help to drive market growth in Asia-Pacific.

Peptide Synthesis Market Leading Companies

The peptide synthesis market players profiled in the report is Biotage, Thermo Fisher Scientific Inc., Creative Diagnostics, Puresynth Research Chemicals Pvt Ltd., GenScript, Syngene International Limited, PolyPeptide Group, Lonza, Merck KGaA, and Bachem Holding AG.

Peptide Synthesis Market Regions